“Click??to??Chelate”: Design and Incorporation of Triazole??Containing Metal??Chelating Systems into Biomolecules of Diagnostic and Therapeutic Interest

H Struthers, B Spingler, TL Mindt…

Index: Struthers, Harriet; Spingler, Bernhard; Mindt, Thomas L.; Schibli, Roger Chemistry - A European Journal, 2008 , vol. 14, # 20 p. 6173 - 6183

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Citation Number: 140

Abstract

Abstract The site-specific conjugation of metal chelating systems to biologically relevant molecules is an important contemporary topic in bioinorganic and bioorganometallic chemistry. In this work, we have used the Cu I-catalyzed cycloaddition of azides and terminal alkynes to synthesise novel ligand systems, in which the 1, 2, 3-triazole is an integral part of the metal chelating system. A diverse set of bidentate alkyne building blocks with different ...