Selective cell death by photochemically induced pH imbalance in cancer cells

…, CO Yanez, S Yao, KD Belfield

Index: Yue, Xiling; Yanez, Ciceron O.; Yao, Sheng; Belfield, Kevin D. Journal of the American Chemical Society, 2013 , vol. 135, # 6 p. 2112 - 2115

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Citation Number: 32

Abstract

Singlet oxygen sensitized photodynamic therapy (PDT) relies on the concentration of oxygen in the tissue to be treated. Most cancer lesions, however, have poor vasculature and, as a result, are hypoxic, significantly hindering PDT efficacies. An oxygen-independent PDT method may circumvent this limitation. To address this, we prepared sulfonium salts that produced a pH drop within HCT 116 cells via the generation of a photoacid within the ...