Synthesis and antifungal activity of terpenyl-1, 4-naphthoquinone and 1, 4-anthracenedione derivatives

…, AC Mesa-Arango, L Betancur-Galvis…

Index: Castro, Ma Angeles; Gamito, Ana Ma; Tangarife-Castano, Veronica; Zapata, Bibiana; Miguel Del Corral, Jose Ma; Mesa-Arango, Ana C.; Betancur-Galvis, Liliana; San Feliciano, Arturo European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 19 - 27

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Citation Number: 11

Abstract

Abstract The antifungal evaluation of twenty seven simple and heterocycle-fused prenyl-1, 4- naphthoquinones and 1, 4-anthracenediones was performed in vitro against human pathogenic yeasts (Candida spp.) and filamentous fungi (Aspergillus spp., Fusarium spp., and Trichophyton spp.). The synthetic strategy used to obtain the quinone derivatives was initially based on the Diels–Alder cycloaddition between myrcene and several p- ...