Towards the enantioselective synthesis of (−)-euonyminol–preparation of a fully functionalised lower-rim model

…, M Weston, S Clark, SJ Woodhead, L Powell…

Index: Webber, Matthew J.; Warren, Sarah A.; Grainger, Damian M.; Weston, Matthew; Clark, Stacy; Woodhead, Steven J.; Powell, Lyn; Stokes, Stephen; Alanine, Alexander; Stonehouse, Jeffrey P.; Frampton, Christopher S.; White, Andrew J. P.; Spivey, Alan C. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 15 p. 2514 - 2533

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Citation Number: 10

Abstract

The development of a stereoselective total synthesis of β-dihydroagarofuran 4 is described. This compound contains the same oxygenation pattern on its 'lower-rim'as found in the natural sesquiterpene (−)-euonyminol (1) and it is expected that the route described should be applicable to the synthesis of that complex natural product.(−)-Euonyminol is found as the core scaffold of a series of complex macrodilactone sesquiterpenoids isolated from the ...