Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies
L Trzoss, J Xu, MH Lacoske, WC Mobley…
Index: Trzoss, Lynnie; Xu, Jing; Lacoske, Michelle H.; Mobley, William C.; Theodorakis, Emmanuel A. Chemistry - A European Journal, 2013 , vol. 19, # 20 p. 6398 - 6408
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Citation Number: 28
Abstract
Abstract Majucin-type sesquiterpenes from Illicium sp., such as jiadifenolide (2), jiadifenin (3), and (1R, 10S)-2-oxo-3, 4-dehydroxyneomajucin (4, ODNM), possess a complex caged chemical architecture and remarkable neurotrophic activities. As such, they represent attractive small-molecule leads against various neurodegenerative diseases. We present an efficient, enantioselective, and unified synthesis of 2, 3, and 4 and designed analogues ...
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