Liebigs Annalen der Chemie

threo??3??Alkyl??and??Arylglutamic Acid Derivatives by Michael Additions of Boc??BMI Li??Enolates to 2, 6??Di??t??butyl??4??methoxyphenyl Alkenoates on the …

K Suzuki, D Seebach

Index: Suzuki, Keisuke; Seebach, Dieter Liebigs Annalen der Chemie, 1992 , # 1 p. 51 - 62

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Citation Number: 24

Abstract

Abstract The conjugated esters 5, 6, 8, 9 mentioned in the title are prepared from the corresponding aryl acetate 4 and aldehydes by aldol condensation (direct enoylation of the hindered phenol with the corresponding unsaturated acid chlorides gave only poor yields). To avoid double-bond shifts, the 4-phenyl 2-butenoate 7a was prepared from the saturated one by selenation/elimination (see 7b, c in Scheme 1). In contrast to methyl and ethyl ...