Synthesis

Copper (II) tetrafluoroborate-catalyzed acetylation of phenols, thiols, alcohols, and amines

AK Chakraborti, R Gulhane

Index: Chakraborti, Asit K.; Gulhane, Rajesh; Shivani Synthesis, 2004 , # 1 p. 111 - 115

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Citation Number: 37

Abstract

Abstract Copper (II) tetrafluoroborate efficiently catalyzes acetylation of structurally diverse phenols, alcohols, thiols, and amines with stoichiometric amounts of Ac 2 O under solvent- free conditions at room temperature. Acid-sensitive alcohols are smoothly acetylated without competitive side reactions. The reaction is influenced by the steric and electronic factors associated with the substrate as well as the anhydride. Acetylation of a sterically hindered ...