Developing microcolin A analogs as biological probes
AK Mandal, J Hines, K Kuramochi, CM Crews
Index: Mandal, Amit K.; Hines, John; Kuramochi, Kouji; Crews, Craig M. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4043 - 4047
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Citation Number: 18
Abstract
Three microcolin A and B analogs have been synthesized. Their biological activity profiles were evaluated against several cell lines, revealing the existence of a structural determinant whose role in mediating the antiproliferative effect of the microcolins has heretofore gone unrecognized. While previously described as potent immunosuppressive natural products, we found that these microcolin analogs possessed no selective cytotoxicity when ...
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