Total Synthesis of aspercyclides A and B via intramolecular oxidative diaryl ether formation

T Yoshino, I Sato, M Hirama

Index: Yoshino, Tatsuya; Sato, Itaru; Hirama, Masahiro Organic Letters, 2012 , vol. 14, # 16 p. 4290 - 4292

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Citation Number: 15

Abstract

A highly efficient total synthesis of the 11-membered cyclic aspercyclides A (1) and B (2) has been achieved by chemo- and regioselective intramolecular oxidative C–O bond formation from differently substituted diphenols. ... In 2004, Singh and co-workers isolated and characterized aspercyclides A (1), B (2), and C from the fermentation broth of Aspergillus sp.(1) Aspercyclide A (1) inhibited the binding of immunoglobulin E antibodies (IgE) to the human IgE ...