Development of a general, sequential, ring-closing metathesis/intramolecular cross-coupling reaction for the synthesis of polyunsaturated macrolactones
SE Denmark, JM Muhuhi
Index: Denmark, Scott E.; Muhuhi, Joseck M. Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11768 - 11778
Full Text: HTML
Citation Number: 30
Abstract
A general strategy for the construction of macrocyclic lactones containing conjugated Z, Z-1, 3-diene subunits is described. The centerpiece of the strategy is a sequential ring-closing metathesis (RCM) that forms an unsaturated siloxane ring, followed by an intramolecular cross-coupling reaction with a pendant alkenyl iodide. A highly modular assembly of the various precursors allowed the preparation of unsaturated macrolactones containing 11-, ...
Related Articles:
First enantioselective total synthesis of penicimarin B, aspergillumarins A and B
[Yadav, Jhillu Singh; Mishra, Anand Kumar; Dachavaram, Soma Shekar; Ganesh Kumar; Das, Saibal Tetrahedron Letters, 2014 , vol. 55, # 18 p. 2921 - 2923]
Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection
[Wisastra, Rosalina; Kok, Petra A.M.; Eleftheriadis, Nikolaos; Baumgartner, Matthew P.; Camacho, Carlos J.; Haisma, Hidde J.; Dekker, Frank J. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 24 p. 7763 - 7778]