Synthesis of enantiomerically pure α-[4-(1-substituted)-1, 2, 3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential …
D Castagnolo, F Dessì, M Radi, M Botta
Index: Castagnolo, Daniele; Dessi, Filippo; Radi, Marco; Botta, Maurizio Tetrahedron Asymmetry, 2007 , vol. 18, # 11 p. 1345 - 1350
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Citation Number: 23
Abstract
Chiral 1-phenyl-2-propynylamines are important building blocks for the synthesis of antifungal and antiaromatase agents related to bifonazole. In this report, a microwave- assisted Cu (I)-catalyzed 'click chemistry'approach has been employed to easily generate a small library of enantiomerically pure α-[4-(1-substituted)-1, 2, 3-triazol-4-yl] benzylacetamides starting from racemic propargylamines. These compounds could ...
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