Scalable, divergent synthesis of meroterpenoids via “borono-sclareolide”

DD Dixon, JW Lockner, Q Zhou…

Index: Dixon, Darryl D.; Lockner, Jonathan W.; Zhou, Qianghui; Baran, Phil S. Journal of the American Chemical Society, 2012 , vol. 134, # 20 p. 8432 - 8435

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Citation Number: 37

Abstract

A scalable, divergent synthesis of bioactive meroterpenoids has been developed. A key component of this work is the invention of “borono-sclareolide”, a terpenyl radical precursor that enables gram-scale preparation of (+)-chromazonarol. Subsequent synthetic operations on this key intermediate permit rapid access to a variety of related meroterpenoids, many of which possess important biological activity.