Camptothecin-related alkaloids from hairy roots of Ophiorrhiza pumila

…, S Yoshida, K Yamagata, M Nakamura, H Takayama…

Index: Kitajima, Mariko; Yoshida, Satoshi; Yamagata, Kyoko; Nakamura, Mio; Takayama, Hiromitsu; Saito, Kazuki; Seki, Hiroko; Aimi, Norio Tetrahedron, 2002 , vol. 58, # 45 p. 9169 - 9178

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Citation Number: 39

Abstract

Hairy roots of Ophiorrhiza pumila, a rubiaceous camptothecin-producing plant, were obtained. From an investigation of the secondary metabolites, it was found that the hairy roots produced camptothecin and its related alkaloids, ie (3S)-pumiloside,(3S)-and (3R)- deoxypumilosides and strictosamide. We also isolated two new camptothecinoids, OPHR-23 and OPHR-17, the structures of which including the absolute configurations, were ...