Syntheses of isotopically labeled 4??[1??(3, 5, 5, 8, 8??pentamethyl??5, 6, 7, 8??tetrahydro??2??naphthyl) ethenyl] benzoic acid (LGD1069), a potent retinoid x receptor?? …
…, BA Badea, D Enyeart, EM Berger…
Index: Zhang; Badea; Enyeart; Berger; Mais; Boehm Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 7 p. 701 - 712
Full Text: HTML
Citation Number: 7
Abstract
Abstract LGD1069, 4-[1-(3, 5, 5, 8, 8-pentamethyl-5, 6, 7, 8-tetrahydro-2-naphthyl) ethenyl] benzoic acid, is the first retinoid X receptor (RXR) selective retinoid to enter clinical trials for treatment of dermatological diseases and cancer. In order to examine biological properties such as receptor binding, metabolism and bioavailability,[13 C]-,[14 C]-, and [3 H]-labeled LGD1069 is required. Herein, we describe synthetic methods for preparing isotopically ...
Related Articles:
Synthesis of novel retinoid X receptor-selective retinoids
[Faul; Ratz; Sullivan; Trankle; Winneroski Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782]
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids
[Boehm; Zhang; Badea; White; Mais; Berger; Suto; Goldman; Heyman Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2930 - 2941]
[Dawson; Jong; Hobbs; Cameron; Chao; Pfahl; Lee -; Shroot Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3368 - 3383]
Synthesis of novel retinoid X receptor-selective retinoids
[Faul; Ratz; Sullivan; Trankle; Winneroski Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782]
Synthesis of novel retinoid X receptor-selective retinoids
[Faul; Ratz; Sullivan; Trankle; Winneroski Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782]