Canadian Journal of Chemistry

SYNTHESIS OF THE ISOMERIC METHYL vic-BROMOFLUOROPROPANOATES

FH Dean, FLM Pattison

Index: Dean,F.H.; Pattison,F.L.M. Canadian Journal of Chemistry, 1965 , vol. 43, p. 2415 - 2418

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Citation Number: 9

Abstract

The addition of "BrF" to methyl methacrylate proceeded in good yield to give 1neth~-1 3-bromo-2-fluoro-2-methylpropanoate as the single product. The n.1n.r. spectrum provided unequivocal proof of structure, as described in the Experimental section. To obtain methyl 3-bromo-2-fluoropropanoate (11) in reasonable yield, it was necessary to select a precursor which did not have the electronic features of the a-allienoic acids. Ally1 acetate was first examined, and was found to give ...