Arylnitroalkenes as scavengers of macrophage-generated oxidants

…, R Frache, N Cataldo, H Cerecetto, M González…

Index: Celano, Laura; Carabio, Claudio; Frache, Renata; Cataldo, Nicolas; Cerecetto, Hugo; Gonzalez, Mercedes; Thomson, Leonor European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 31 - 40

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Citation Number: 3

Abstract

Abstract Oxygen and nitrogen derived molecules mediated oxidation and nitration have been involved in several pathological conditions. Conversely, nitric oxide and hydrogen peroxide are important signalization intermediates, whose concentrations are tightly regulated by specialized enzyme repertoires and should remain undisturbed by the addition of exogenous antioxidant molecules, as already demonstrated by intervention studies with ...