Synthesis and testing of heterocyclic analogs of diaminopimelic acid (DAP) as inhibitors of DAP dehydrogenase and DAP epimerase
…, P Lane-Bell, KPS Sidhu, JC Vederas
Index: Abbott, Shaun D.; Lane-Bell, Patricia; Sidhu, Kanwar P. S.; Vederas, John C. Journal of the American Chemical Society, 1994 , vol. 116, # 15 p. 6513 - 6520
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Citation Number: 52
Abstract
Abstract: Substrate analogues were synthesized and examined as inhibitors of diaminopimelic acid (DAP) dehydrogenase from Bacillus sphaericus and of DAP epimerase from Escherichia coli. These enzymes produce meso-DAP (3)(a precursor for L-lysine and ...
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