Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4, 6-Dehydratase
…, YJ Kim, S Caille, M Achmatowicz, O Thiel…
Index: Thiel, Oliver R.; Achmatowicz, Michal M. Organic Syntheses, 2013 , vol. 90, p. 287 - 300
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Abstract
The efficacy of therapeutic antibodies that induce antibody-dependent cellular cytotoxicity can be improved by reduced fucosylation. Consequently, fucosylation is a critical product attribute of monoclonal antibodies produced as protein therapeutics. Small molecule
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