Efficient Synthesis of 3-Substituted 1, 2, 4-Triazolo [4, 3-a] pyridine by [Bis (Trifluroacetoxy) iodo] benzene-Catalyzed Oxidative Intramolecular Cyclization of …

VS Padalkar, VS Patil, KR Phatangare…

Index: Padalkar, Vikas S.; Patil, Vikas S.; Phatangare, Kiran R.; Umape, Prashant G.; Sekar Synthetic Communications, 2011 , vol. 41, # 6 p. 925 - 938

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Citation Number: 13

Abstract

Abstract A series of 1, 2, 4-triazolopyridines have been prepared by oxidative intramolecular cyclization of heterocyclic hydrazones with [bis (trifluroacetoxy) iodo] benzene. General applicability of this simple transformation was confirmed by synthesis of 1, 2, 4-triazolo [4, 3- a] pyridine. The advantages of this protocol are the nontoxicity of catalyst and shorter reaction time to obtain good preparative yield.