Novel diphenylalkyl piperazine derivatives with dual calcium antagonistic and antioxidative activities
…, T Masuda, K Yamada, N Kubota, N Kawakatsu…
Index: Kimura, Makoto; Masuda, Tomoko; Yamada, Koji; Kubota, Nobuo; Kawakatsu, Nobuyuki; Mitani, Masaki; Kishii, Kenichi; Inazu, Masato; Namiki, Takayuki Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 15 p. 1947 - 1950
Full Text: HTML
Citation Number: 20
Abstract
Two types of novel diphenylalkyl piperazine derivatives containing the thio or aminopropanol moiety substituted by phenyl or benzyl group were synthesized, and evaluated for their calcium antagonistic and antioxidative activities. These compounds showed apparent inhibitions against KCl-induced contractions in isolated rat aorta. Among them, phenylamino compound 9 and benzylamino compound 13 also possessed potent ...
Related Articles:
[Pace, Vittorio; Hoyos, Pilar; Sinisterra, Jose Vicente; Alcantara, Andres R.; Holzer, Wolfgang Synlett, 2011 , # 13 p. 1831 - 1834]
[Temple, Carroll; Wheeler, Glynn P.; Elliott, Robert D.; Rose, Jerry D.; Kussner, Conrad L.; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1045 - 1050]
[Pace, Vittorio; Hoyos, Pilar; Sinisterra, Jose Vicente; Alcantara, Andres R.; Holzer, Wolfgang Synlett, 2011 , # 13 p. 1831 - 1834]