Novel Cytidine-Based Orotidine-5′-Monophosphate Decarboxylase Inhibitors with an Unusual Twist

…, E Poduch, LW Wei, IE Crandall…

Index: Purohit, Meena K.; Poduch, Ewa; Wei, Lianhu William; Crandall, Ian Edward; To, Terrence; Kain, Kevin C.; Pai, Emil F.; Kotra, Lakshmi P. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9988 - 9997

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Citation Number: 4

Abstract

Orotidine-5′-monophosphate decarboxylase (ODCase) is an interesting enzyme with an unusual catalytic activity and a potential drug target in Plasmodium falciparum, which causes malaria. ODCase has been shown to exhibit unusual and interesting interactions with a variety of nucleotide ligands. Cytidine-5′-monophosphate (CMP) is a poor ligand of ODCase, and CMP binds to the active site of ODCase with an unusual orientation and ...