The first silicon (IV) phthalocyanine–nucleoside conjugates with high photodynamic activity

…, BY Zheng, XR Huang, L Wang, JD Huang

Index: Shen, Xiao-Min; Zheng, Bi-Yuan; Huang, Xiu-Rong; Wang, Lei; Huang, Jian-Dong Dalton Transactions, 2013 , vol. 42, # 29 p. 10398 - 10403

Full Text: HTML

Citation Number: 15

Abstract

A series of novel silicon (IV) phthalocyanines conjugated axially with different nucleoside moieties (uridine, 5-methyluridine, cytidine, and 5-N-cytidine derivatives) have been synthesized and evaluated for their photodynamic activities. The uridine-containing compound 1 exhibits the highest photocytotoxicity against HepG2 human hepatocarcinoma cells with an IC50 value as low as 6 nM, which can be attributed to its high cellular uptake ...