Preparation of unlabelled and [3 H]-labelled epitestosterone and its metabolites
A Kasal, K Fuksová, V Pouzar
Index: Kasal, Alexander; Fuksova, Kveta; Pouzar, Vladimir Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 3 p. 600 - 611
Full Text: HTML
Citation Number: 12
Abstract
Abstract Cold as well as [3 H]-labelled substrates and metabolites IX-XI, XV, XVI, XX-XXII, XXIV, XXV and XXVIII were prepared by catalytic hydrogenation of epitestosterone (VIII) and∆ 1-dehydroepitestosterone (XIII). The key step in the preparation of compound XXVIII was reaction of 3β-tosylates XXVI and XXX with potassium nitrite in dimethyl sulfoxide.
Related Articles:
Iodosobenzene diacetate, an efficient reagent for the oxidative decarboxylation of carboxylic acids
[Concepcion, J. I.; Francisco, C. G.; Freire, R.; Hernandez, R.; Salazar, J. A.; Suarez, E. Journal of Organic Chemistry, 1986 , vol. 51, # 3 p. 402 - 404]
Hypocholesterolemic agents. 7. C-17 epimer of 20, 25-diazacholesterol
[Ranade,V.V. et al. Journal of Medicinal Chemistry, 1971 , vol. 14, p. 38 - 40]