Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

F Amblard, B Govindarajan, B Lefkove, KL Rapp…

Index: Amblard, Franck; Govindarajan, Baskaran; Lefkove, Benjamin; Rapp, Kimberly L.; Detorio, Mervi; Arbiser, Jack L.; Schinazi, Raymond F. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4428 - 4431

Full Text: HTML

Citation Number: 52

Abstract

A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti- proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.