Glucuronide production by whole-cell biotransformation using genetically engineered fission yeast Schizosaccharomyces pombe

…, D Buchheit, D Bischoff, T Ebner, M Bureik

Index: Dragan, Calin-Aurel; Buchheit, Daniela; Bischoff, Daniel; Ebner, Thomas; Bureik, Matthias Drug Metabolism and Disposition, 2010 , vol. 38, # 3 p. 509 - 515

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Citation Number: 21

Abstract

Abstract Drug metabolites generated by UDP glycosyltransferases (UGTs) are needed for drug development and toxicity studies, especially in the context of safety testing of metabolites during drug development. Because chemical metabolite synthesis can be arduous, various biological approaches have been developed; however, no whole-cell biotransformation with recombinant microbes that express human UGTs was yet achieved. ...