Toward an optimal joint recognition of the S1'subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase ( …

…, H Meudal, F Teffot, MC Fournié-Zaluski…

Index: Inguimbert, Nicolas; Coric, Pascale; Poras, Herve; Meudal, Herve; Teffot, Franck; Fournie-Zaluski, Marie-Claude; Roques, Bernard P. Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1477 - 1486

Full Text: HTML

Citation Number: 25

Abstract

The formation of vasoconstrictors (eg, angiotensin II and endothelin) and the inactivation of vasodilators (eg, bradykinin and atrial natriuretic) by membrane-bound zinc metallopeptidases are key mechanisms in the control of blood pressure and fluid homeostasis. The way in which these peptides modulate physiological functions has been intensively studied. With the aim to develop compounds that can jointly block the three ...

Related Articles:

l-Threonine-Derived Novel Bifunctional Phosphine− Sulfonamide Catalyst-Promoted Enantioselective Aza-Morita− Baylis− Hillman Reaction

[Han, Xiaoyu; Wang, Youqing; Zhong, Fangrui; Lu, Yixin Journal of the American Chemical Society, 2011 , vol. 133, # 6 p. 1726 - 1729]

Enantioselective Enolate Protonation in Sulfa–Michael Addition to α-Substituted N-Acryloyloxazolidin-2-ones with Bifunctional Organocatalyst

[Rana, Nirmal K.; Singh, Vinod K. Organic Letters, 2011 , vol. 13, # 24 p. 6520 - 6523]

Enantioselective Enolate Protonation in Sulfa–Michael Addition to α-Substituted N-Acryloyloxazolidin-2-ones with Bifunctional Organocatalyst

[Rana, Nirmal K.; Singh, Vinod K. Organic Letters, 2011 , vol. 13, # 24 p. 6520 - 6523]

More Articles...