Organic letters

l-Threonine-Derived Novel Bifunctional Phosphine− Sulfonamide Catalyst-Promoted Enantioselective Aza-Morita− Baylis− Hillman Reaction

F Zhong, Y Wang, X Han, KW Huang, Y Lu

Index: Han, Xiaoyu; Wang, Youqing; Zhong, Fangrui; Lu, Yixin Journal of the American Chemical Society, 2011 , vol. 133, # 6 p. 1726 - 1729

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Citation Number: 66

Abstract

A series of novel bifunctional phosphine− sulfonamide organic catalysts were designed and readily prepared from natural amino acids, and they were utilized to promote enantioselective aza-Morita− Baylis− Hillman (MBH) reactions. l-Threonine-derived phosphine− sulfonamide 9b was found to be the most efficient catalyst, affording the desired aza-MBH adducts in high yields and with excellent enantioselectivities.

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