Synthesis of β??Methoxyacrylate Natural Products Based on Box??PdII??Catalyzed Intermolecular Methoxycarbonylation of Alkynoles

…, T Kusakabe, S Katoh, H Akita, K Kato

Index: Motodate, Satoshi; Kobayashi, Takuya; Fujii, Mikio; Mochida, Tomoyuki; Kusakabe, Taichi; Katoh, Shigeki; Akita, Hiroyuki; Kato, Keisuke Chemistry - An Asian Journal, 2010 , vol. 5, # 10 p. 2221 - 2230

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Citation Number: 17

Abstract

Abstract Bis (oxazoline)-palladium (II) catalyzed carbonylation of homopropargyl alcohols afforded acyclic methoxyacrylate 2 and 6-membered lactone 3a, 3b, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k in good combined yield. In the case of propargyl alcohols, 5-membered lactones 3p, 3q, 16 were obtained in moderate yields. The one-pot synthesis of kawa lactones 3a, 3r, 3s and formal synthesis of dihydroxycystothiazole A and dihydroxycystothiazole C are presented. ...