Heck–Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues

C Soldi, AV Moro, MG Pizzolatti…

Index: Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D. European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616

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Citation Number: 9

Abstract

Abstract Herein, we describe the total syntheses of three bioactive pyrones isolated from Polygala sabulosa (ie, 1, 4, and 7) and eight isolated from Piper methysticum (ie, 8–10, 13, 15, and 18–20) using the Heck–Matsuda arylation as the key strategy. The evaluation of this methodology by employing different arenediazonium tetrafluoroborates revealed that the Heck arylation was more efficient when the olefin undergoing arylation possessed the ...