Synthesis of Chiral Benzimidazoles as Acylating Agents for Kinetic Resolution of Racemic α??Amino Esters

H Xu, H Tian, L Zheng, Q Liu, L Wang…

Index: Xu, Hao; Tian, Hua; Liu, Qingwen; Wang, Li; Zhang, Suoqin; Zheng, Liangyu Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 5 p. 1108 - 1113,6

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Abstract

Abstract A series of novel chiral 1-benzoyl-2-(α-N-substituted aminoethyl) benzimidazoles are synthesized with the improved method in high yields (72–84%) and developed as nonenzymatic acylating agents for kinetic resolution of racemic α-amino esters. The process exhibits high enantioselectivity (ee up to 94%) for α-amino esters under mild reaction conditions.

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