Tetrahedron: Asymmetry

Asymmetric synthesis of uncommon α-amino acids by diastereoselective alkylations of a chiral glycine equivalent

K Tanaka, M Ahn, Y Watanabe, K Fuji

Index: Tanaka, Kiyoshi; Ahn, Mija; Watanabe, Yukari; Fuji, Kaoru Tetrahedron Asymmetry, 1996 , vol. 7, # 6 p. 1771 - 1782

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Citation Number: 44

Abstract

For the purpose of practical preparations of a variety of enantiomerically pure uncommon α- amino acids, alkylations of the chiral glycine equivalent 5, which possesses axially chiral binaphthol as an auxiliary, with several electrophiles were investigated. The alkylation proceeded smoothly in satisfactory chemical yield with high diastereoselectivities to give protected α-amino acid derivatives. The free hydroxyl group of the auxiliary played an ...

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