Preparation of human drug metabolites using fungal peroxygenases
M Poraj-Kobielska, M Kinne, R Ullrich…
Index: Poraj-Kobielska, Marzena; Kinne, Matthias; Ullrich, Rene; Scheibner, Katrin; Kayser, Gernot; Hammel, Kenneth E.; Hofrichter, Martin Biochemical Pharmacology, 2011 , vol. 82, # 7 p. 789 - 796
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Citation Number: 34
Abstract
The synthesis of hydroxylated and O-or N-dealkylated human drug metabolites (HDMs) via selective monooxygenation remains a challenging task for synthetic organic chemists. Here we report that aromatic peroxygenases (APOs; EC 1.11. 2.1) secreted by the agaric fungi Agrocybe aegerita and Coprinellus radians catalyzed the H2O2-dependent selective monooxygenation of diverse drugs, including acetanilide, dextrorphan, ibuprofen, ...
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