Substituted 3-(4-(1, 3, 5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors

…, A Devasagayaraj, K Gu, B Marinelli, L Samala…

Index: Jin, Haihong; Cianchetta, Giovanni; Devasagayaraj, Arokiasamy; Gu, Kunjian; Marinelli, Brett; Samala, Lakshman; Scott, Sheldon; Stouch, Terry; Tunoori, Ashok; Wang, Ying; Zang, Yi; Zhang, Chengmin; David Kimball; Main, Alan J.; Ding, Zhi-Ming; Sun, Weimei; Yang, Qi; Yu, Xiang-Qing; Powell, David R.; Wilson, Alan; Liu, Qingyun; Shi, Zhi-Cai Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 5229 - 5232

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Citation Number: 20

Abstract

Tryptophan hydroxylase (TPH) is a key enzyme in the synthesis of serotonin. As a neurotransmitter, serotonin plays important physiological roles both peripherally and centrally. Here we describe the discovery of substituted triazines as a novel class of tryptophan hydroxylase inhibitors. This class of TPH inhibitors can selectively reduce serotonin levels in murine intestine after oral administration without affecting levels in the ...