Anti-AIDS agents. 60. Substituted 3'R, 4'R-di-O-(-)-camphanoyl-2', 2'-dimethyldihydropyrano [2, 3-f] chromone (DCP) analogues as potent anti-HIV agents
D Yu, CH Chen, A Brossi, KH Lee
Index: Yu, Donglei; Chen, Chin-Ho; Brossi, Arnold; Lee, Kuo-Hsiung Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 4072 - 4082
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Citation Number: 73
Abstract
Synthesis of positional isomers is a commonly used technique in drug design. Accordingly, based on prior SAR studies of 3'R, 4'R-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK, 1) analogues, a series of mono-and disubstituted chromone derivatives of 3'R, 4'R-di-O-(-)- camphanoyl-2', 2'-dimethyldihydropyrano [2, 3-f] chromone (DCP, 4) were designed and synthesized. Together with 1 and 4-methyl DCK (2), all newly synthesized DCP analogues ...
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