Nonsteroidal anti-inflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase

…, T Capiris, WJ Cetenko, DT Connor…

Index: Flynn; Capiris; Cetenko; Connor; Dyer; Kostlan; Nies; Schrier; Sircar Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2070 - 2072

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Citation Number: 43

Abstract

is currently an important area of clinical research. Thus CO inhibition by NSAIDs removes a natural cytoprotective mechanism. In searching for NSAID classes with a broader mechanistic profile and reduced side effect liability, we have noted that evidence has accumulated which implicates uninhibited or increased leukotriene production in addition to prostaglandin inhibition as a more complete explanation for these NSAID-induced side ...

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