Discovery of new photoactivatable diaryltetrazoles for photoclick chemistry via 'scaffold hopping'

Z Yu, LY Ho, Z Wang, Q Lin

Index: Yu, Zhipeng; Ho, Lok Yin; Wang, Zhiyong; Lin, Qing Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5033 - 5036

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Citation Number: 32

Abstract

We report the discovery of two long-wavelength (365nm) photoactivatable diaryltetrazoles through screening a small library of diaryltetrazoles that were designed using a 'scaffold hopping'strategy. A naphthalene-derived tetrazole showed excellent reactivity in the photoinduced cycloaddition reaction with methyl methacrylate under 365nm photoirradiation in acetonitrile PBS buffer mixture. Besides, the brightly fluorescent pyrazoline ...