Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors

…, T Honoré, P Krogsgaard-Larsen

Index: Lauridsen, Joern; Honore, Tage; Krogsgaard-Larsen, Povl Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 668 - 672

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Citation Number: 102

Abstract

(RS)-a-amino-3-hydroxy-5-isoxazolevaleric acid (15b) are described. The compounds were tested in vitro together with (RS)-a-amino-3-hydroxy-5-(bromomethyl)-4-isoxazolepropionic acid (ABPA) as inhibitors of the binding of radioactive-labeled (RS)-a-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) to rat brain synaptic membranes. These data were compared with the earlier reported effects of the compounds on single neurons in the ...

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