Excitatory amino-acid receptor agonists. Synthesis and pharmacology of analogues of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid

FA Sløk, B Ebert, Y Lang, P Krogsgaard-Larsen…

Index: Slok; Ebert; Lang; Krogsgaard-Larsen; Lenz; Madsen European Journal of Medicinal Chemistry, 1997 , vol. 32, # 4 p. 329 - 338

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Citation Number: 32

Abstract

We have previously proposed the existence of a lipophilic cavity of the 2-amino-3-(3-hydroxy- 5-methylisoxazol-4-yl) propionic acid (AMPA) receptor recognition site capable of accommodating alkyl substituents of limited size in the 5-position of the isoxazole ring. In order to indirectly elucidate the approximate extent of this proposed cavity we have synthesized and pharmacologically characterized a number of AMPA analogues. For most ...