A new synthesis of 5-trifluoromethyluracil

P Andres, A Marhold

Index: Andres, Peter; Marhold, Albrecht Journal of Fluorine Chemistry, 1996 , vol. 77, # 1 p. 93 - 95

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Citation Number: 21

Abstract

5-Trifluoromethyluracil, an important intermediate for the preparation of the antiviral trifluridine, is obtained by chlorinating thymine to give the new 2, 4-dichloro-5- trichloromethylpyrimidine. Reacting the latter with hydrogen fluoride yields the new 2, 4- difluoro-5-trifluoromethylpyrimidine, and hydrolysis with water gives 5-trifluoromethyluracil in high purity and good yield.