Biocatalytic oxidation of 2-methylquinoxaline to 2-quinoxalinecarboxylic acid
…, EL McCormick, DA Scully, JM Siderewicz…
Index: Wong, John W.; Watson Jr., Harry A.; Bouressa, James F.; Burns, Michael P.; Cawley, James J.; Doro, Albert E.; Guzek, Donald B.; Hintz, Michael A.; McCormick, Ellen L.; Scully, Douglas A.; Siderewicz, Joseph M.; Taylor, William J.; Truesdell, Susan J.; Wax, Richard G. Organic Process Research and Development, 2002 , vol. 6, # 4 p. 477 - 481
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Citation Number: 18
Abstract
A microbial process using the fungus Absidia repens ATCC 14849 is described for the oxidation of 2-methylquinoxaline to 2-quinoxalinecarboxylic acid. A campaign consisting of three 14000-L runs produced 20.5 kg of the acid with a 28% overall yield. The bioconversion gave a lower yield compared with a three step chemical synthesis (35%), but was carried out in one pot, and avoided safety issues with a di-N-oxide intermediate. Although ...
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