Design, synthesis and structure–activity relationship of novel quinoxalin-2-carboxamides as 5-HT 3 receptor antagonists for the management of depression

R Mahesh, T Devadoss, DK Pandey, S Bhatt…

Index: Mahesh, Radhakrishnan; Devadoss, Thangaraj; Pandey, Dilip Kumar; Bhatt, Shvetank; Yadav, Shushil Kumar Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6773 - 6776

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Citation Number: 14

Abstract

A novel series of quinoxalin-2-carboxamides were designed based on the ligand-based approach, employing a three-point pharmacophore model; it consists of an aromatic residue and a linking carbonyl group and a basic nitrogen. The target new chemical entities were synthesized from the key intermediate, quinoxalin-2-carboxylic acid, by coupling it with various amines in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide ...