Efficient method for the preparation of (S)-5-hydroxynorvaline

M Garcı́a, A Serra, M Rubiralta, A Diez, V Segarra…

Index: Garcia, Monica; Serra, Anna; Rubiralta, Mario; Diez, Anna; Segarra, Victor; Lozoya, Estrella; Ryder, Hamish; Palacios, Jose M. Tetrahedron Asymmetry, 2000 , vol. 11, # 4 p. 991 - 994

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Citation Number: 8

Abstract

(S)-5-Hydroxynorvaline 4 has been prepared from l-glutamic acid 1 by simultaneous protection of the α-amino and α-carboxyl groups, and selective reduction of the resulting boroxazolidone 2. This method is rapid and highly reproducible, and gives very pure (S)-5- hydroxynorvaline after simple anion-exchange purification. It improves existing methods by providing a purer product in higher yields.

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