Kinetic resolution of unnatural and rarely occurring amino acids: enantioselective hydrolysis of N-acyl amino acids catalyzed by acylase I

…, J Dahmer, GM Whitesides

Index: Chenault, H. Keith; Dahmer, Juergen; Whitesides, George M. Journal of the American Chemical Society, 1989 , vol. 111, # 16 p. 6354 - 6364

Full Text: HTML

Citation Number: 307

Abstract

Abstract: Acylase I (aminoacylase; N-acylamino-acid amidohydrolase, EC 3.5. 1.14. from porcine kidney and the fungus Aspergillus) is a broadly applicable enzymatic catalyst for the kinetic resolution of unnatural and rarely occurring a-amino acids. Its enantioselectivity for the hydrolysis of N-acyl La-amino acids is nearly absolute, yet it accepts substrates having a wide range of structure and functionality. This paper reports the initial rates of enzyme- ...