Three new neuritogenic steroidal saponins from Ophiopogon japonicus (Thunb.) Ker-Gawl

Y Ye, Y Qu, R Tang, S Cao, W Yang, L Xiang, J Qi

Index: Ye, Ying; Qu, Yuan; Tang, Ruiqi; Cao, Shining; Yang, Wei; Xiang, Lan; Qi, Jianhua Steroids, 2013 , vol. 78, # 12-13 p. 1171 - 1176

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Citation Number: 3

Abstract

Abstract Three new steroidal saponins (1–3) and a known saponin (4) were isolated from Ophiopogon japonicus (Thunb.) Ker-Gawl. Their structures were determined by spectroscopic analyses and chemical derivatization. The isolated compounds (1–4) were potent inducers of neuritogenesis on PC12 cells. Compound 1 showed the highest neuritogenic activity of 46% at 1 μM. The study of structure–activity relationships suggests ...