Drug latentiation by. gamma.-glutamyl transpeptidase

…, FN Shirota, HT Nagasawa

Index: Magnan, Sanne D. J.; Shirota, Frances N.; Nagasawa, Herbert T. Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1018 - 1021

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Citation Number: 33

Abstract

The Ny-glutamyl derivatives of~-thiazolidine-4-carboxylic acid, 4-aminobutyric acid, 1- aminocyclopentanecaboxylic acid, 2-aminophenol, and p-fluoro-L-phenylalanine (compounds 6, 8, 9, 10, and 12, respectively) were synthesized using the synthon phthaloylglutamic anhydride. Their relative rates of cleavage by the enzyme y-glutamyl transpeptidase (y-GT) were determined in order to evaluate the possibility for their ...