Low-Valent Niobium-Mediated Double Activation of CF/CH Bonds: Fluorene Synthesis from o-Arylated α, α, α-Trifluorotoluene Derivatives

K Fuchibe, T Akiyama

Index: Fuchibe, Kohei; Akiyama, Takahiko Journal of the American Chemical Society, 2006 , vol. 128, # 5 p. 1434 - 1435

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Citation Number: 123

Abstract

The C−F bond is the strongest single bond connected to carbon. 1 Although several aromatic and aliphatic C−F bond activations have been reported in recent years, 2,3 the development of a novel method for C−F bond activation remains elusive. In particular, the CF 3 group attached to an aromatic ring is surprisingly stable, and the activation of these benzylic C−F bonds is quite limited. 4 The transformation of the CF 3 groups is thus a challenging task from the ...