Structure-activity relationships of (arylalkyl) imidazole anticonvulsants: comparison of the (fluorenylalkyl) imidazoles with nafimidone and denzimol

DW Robertson, JH Krushinski, EE Beedle…

Index: Robertson; Krushinski; Beedle; Leander; Wong; Rathbun Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1577 - 1586

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Citation Number: 39

Abstract

A recently discovered and structurally distinct class of antiepileptic drugs is the (arylalky1) imidazoles. Two independently discovered representatives of this class, denzimol ((~-[4-(2- phenylethyl) pheny1]-1H-imidazole-l-ethanol) and nafimidone (24 1H-imidazol-l-yl)-l-(2- naphthalenyl) ethanone), are undergoing clinical evaluation. Our structure-activity relationship (SAR) studies revealed that in addition to the naphthalenyl and ...