Tetrahedron letters

Improved synthesis of oligonucleotides containing 2-thiouridine derivatives by use of diluted iodine solution

I Okamoto, K Seio, M Sekine

Index: Okamoto, Itaru; Seio, Kohji; Sekine, Mitsuo Tetrahedron Letters, 2006 , vol. 47, # 4 p. 583 - 585

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Citation Number: 16

Abstract

It is known that the 2-thiocarbonyl group of 2-thiouridine (s2U) derivatives reacts easily with various oxidizing agents used in oligonucleotide synthesis to give a complex mixture. In this letter, we report an improved method for the synthesis of oligonucleotides containing s2U derivatives. It turned out that the 2-thiocarbonyl group of oligonucleotides containing s2U derivatives was stable in a 0.02 M solution of iodine in pyridine–THF–H2O. These ...

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