Tetrahedron Letters

Effective synthesis of nucleosides with glycosyl trifluoroacetimidates as donors

J Liao, J Sun, B Yu

Index: Liao, Jinxi; Sun, Jiansong; Yu, Biao Tetrahedron Letters, 2008 , vol. 49, # 34 p. 5036 - 5038

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Citation Number: 11

Abstract

Since the introduction of the silyl variation of the Hilbert-Johnson reaction 1 by Iwai and Nishimura in 1964, 2 many types of glycosyl donors have been applied in the synthesis of a large variety of the nucleosides. Among them, 1-O-acetyl sugars, in the presence of a strong Lewis acid, are the most frequently used glycosyl donors. 3 However, in all these methods, either stoichiometric amount of the promoter or high temperature is required to secure high-yielding of the N- ...

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