Synthesis and dopaminergic activity of 2-substituted octahydrobenzo [f] quinolines

…, SM Torkelson, PR Findell, RI Weiner

Index: Craig, J. Cymerman; Torkelson, Steven M.; Findell, Paul R.; Weiner, Richard I. Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 961 - 968

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Citation Number: 18

Abstract

8: R= 7-OH C: R= 7, 8-(OMe) zd: R= 8.9-(OMe) 2 10: X= CN b: R= 9-OH 8: R= 7-OMe C: R= 7, 8-(OH) 2 b: A= 9-OMe d: R= 8, 9-(OH) 2 c: R= 7, 8-(OMe)? d: R= 8, 9-(OMe), hydronaphthalene"(4a), which was oxidized with m-chloroperoxybenzoic acid to afford the epoxide 5a in quantitative yield. Isomerization of the epoxide to the 2-tetralone 6a was carried out with zinc iodide as Lewis acid catalyst. 12J3 Commercial zinc iodide failed to ...

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